Julio Kaworski wrote:
>I came accross some interesting articles on cell ageing regarding
>a new theory relating to the increased loss of methyl groups from
>the dna in ageing cells. Drs.M.S. Kanungo, Robin Holliday and
>others have postulated that ageing in somatic cells may be due to
>failure of maintenance of the cell. The main mechanism of cell
>memory is methylation. If methyl groups are lost due to cell
>division or otherwise, unwanted proteins will be expressed.In a
>completely separate study Drs. Porter and Smith and other
>researchers have found through cell fusion experiments that with
>advancing age cells express specific proteins that interfere with
>cell division. I was fortunate to have read these separate papers
>and make the link confirming the demethylation hypothesis.These
>studies seem to me crucial to the understanding of cell ageing.If
>any subscriber to this group has information on the subject and
>wish to share it or if anybody is interested in the specifics of
>the articles that I have please post.
>cordially: Julio Karwoski.
Mr. Kaworski,
I am indeed interested in the specifics of the articles - could
you please post details and publication details.
Thank you,
Michelle Olga Visser
Head of Research, Department of Thoracic Surgery
Faculty of Medicine, University of Pretoria
P.O.Box 667, Pretoria, 0001 South Africa
Phone : +27 12 3541677 (W) +27 12 3310701 (H)
E-mail: cryotech at iafrica.com
