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plasmid maps from rest. frag. sizes?

mangalam at SALK-SC2.SDSC.EDU mangalam at SALK-SC2.SDSC.EDU
Mon Sep 21 17:31:32 EST 1992

Brian Foley writes:
>	I am looking for a program (Mac, DOS, or VMS) that will help
>me draw a circular (or linear) map of DNA, given a list of the
>restriction fragment sizes that are observed upon single and
>multiple-enzyme digests.
>	I have looked in the IBMPC and MAC subdirectories of the
>MOLBIO directory of FLY.BIO.INDIANA.EDU FTP site.  I did not see what
>I wanted there, but I may have missed something.

   This is more complex than you might realize (there's a decent discussion
in the CRC book, _Mathematical Methods for DNA sequences_, 1989, ed: Mike
Waterman, ISBN 0-8493-6664-X), but there are a couple of programs that try
to assist this process:

1) COMAP by Kay Hofmann for the IBM PC, can be got at the Indiana FTP site

2) GelReader, now in it's 2.0.3 incarnation available from the NCSA
archives at zaphod.ncsa.uiuc.edu in /pub/mac/GelReader (I think).

Good Luck,


Harry Mangalam                                   Vox:(619) 453-4100, x250
Dept of Biocomputing                                   Fax:(619) 552-1546
The Salk Institute                             mangalam at salk-sc2.sdsc.edu
10010 N Torrey Pines Rd                        mangalam at salk-sgi.sdsc.edu
La Jolla CA 92037                                    mangalam at salk.bitnet

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