I'm another very satisfied GCG customer. Our computing center has recently
switched over to GCG from IG, and I've found GCG to be much more useful
(not necessarily easier to use, but it does more). In particular their
multiple sequence alignment and analysis programs are great. The manual
is well written (for a manual) and very up-to-date (my copy had many entries
dated the same month I got it!); it is also well-referenced, so you can
actually find the references to the algorithms. It does have a learning
Disclaimer: RIGHT! As if anyone would pay me to spout off my opinions!