In article <1994Jan18.103903.17543 at desire.wright.edu>, aarment at desire.wright.edu (The doctor is IN.) writes:
> I am looking for a program (PC, Mac, VAX, or UNIX) that can predict
> antigenicity from a peptide sequence. Is there anyone out there that can point
> me in the right direction? Public domain is preferred, but any suggestions are
> welcomed. Please respond directly to my e-mail account at
>aarment at desire.wright.edu>> Thanks
>> Anthony Arment
> Wright State University
I am sure that you know that "antigen prediction" software only
provides a rough guide to this property and that a knowledge of the
tertiary structure of the protein is an asset in rational prediction.
However, there are a few programs for IBM-PC/DOS that will take a protein
sequence and give some indication as to antigenic regions. I have used
EpiPlot 1.0 and Predict7 and these are available from the EMBL file server.
Either anonymous ftp from ftp.EMBL-Heidelberg.DE or you can collect them
using the EMBL email fileserver;
send an email message to NetServ at EMBL-Heidelberg.DE with the line
in the body of the message. You will need a UUDecoder if you use the
If you want to examine amino acid property profiles of protein
sequences then I thoroughly recommend ProGraph which is also available
from the same source and is slick and quick. If you have any trouble
collecting the software then give me a call.
All the very best,
Bernard Murray, Ph.D.
37/3C25 National Cancer Institute, NIH, Bethesda MD 20892, USA
bernard at elsie.nci.nih.gov - bmurray at helix.nih.gov -  (301) 496-0731