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Cameleon: Sequence analysis

Tod Klingler klingler at cmgm.stanford.edu
Tue Mar 15 17:13:44 EST 1994

bclong at uxmail.ust.hk (Terence) writes:

>	Has anyone ever heard of a sequence analysis/alignment software
>called Cameleon from Oxford Molecular. What platform(s) does it run on?
>We are looking for powerful protein sequence analysis software. Any
>idea what this, and possibly other, package can provide?
>Thanks in advance.

Cameleon is Oxford Molecular's protein sequence homology modeling program.
It has an interactive graphical environment for aligning sequences (alignments
can be read in or automatically generated, and manually edited) and the ability
to link specific sequences in an alignment to their PDB structures.  Color-
coded context information is automatically updated in both the alignment and
structure--one can choose a column in the alignment and see what position
in a structure it corresponds to (and vica-versa) in real time.

Their newest version (3.0) supports multiple sequence alignments (previous
versions handled only pairwise alignments) and runs on SGI platforms.  The
program is a little clunky, but one of only a couple I know of that can link
sequence alignments to structures directly.

Most of Oxford Molecular's other software is for molecular modeling and
structural analysis--aside from Cameleon and a motif searcher, they have no
other programs for general sequence analysis.


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