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database search results

Chuck Staben staben at seqanal.mi.uky.edu
Tue Mar 15 21:20:27 EST 1994

Database searches are very difficult to interpret-and I find homology (similarity) figures in papers frequently border on the unbelievable, but give no indicators of confidence, even statistical.  In response to the post by brett, the P-values are an indicator of the likelihood that the score of the match could differ from an expected score.  Low P-values indicate clear similarity, high p-values are dubious.  I find that some matches of real biological significance have p-values as low as 0.3 (BLAST searc
es).  Lower values might be signifcant, but I doubt it.  Some higher values are probably not significant.  

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