TopPred II 1.1 (January 1995)
A new release of the TopPred II sofware is now available from the EMBL
server (ftp.ebi.ac.uk) and will be soon available in the SUMEX server
application TopPred II 1.1
authors Claros M.G and von Heijne G.
description Prediction of transmembrane segments in integral
membrane proteins, and the putative topologies
literature CABIOS 10(6), 685-686 (1994)
NOTE A postcript file containing the orignal paper about this
software can be found with the programs. It could be
printed out with the LaserWriter Utility accompanying
the apple printers, or the old Print PS application.
TopPred II is now available in two different versions:
- "TopPredII 1.1" which is "compatible" with any kind of macintosh
- "TopPredII 1.1 FPU" which is a "rapid" version of TopPred. This one
needs a macintosh with a 68020 processor or later, containing an FPU.
This version is significatively faster making profiles and
constructing protein topologies (in several cases up to 6-fold
Modifications from TopPred II 1.0:
o "Open" has been substituted by "Load" in menus
o Minor modifications have been operated in displaying results
o FOS is no longer a TEXT file.
o Previous versions hung when one searched for protein topologies
without any transmembrane domain. This is fixed now.
o Problems reading some sequence files have been fixed.
o G. von Heijne address and the reference to the article about
TopPred II have been updated in the on-line help.
o Finally, some other minor details have been fixed, and several
Bugs not fixed:
o Problems concerning the scroll bar of the text result
window: it is only active when the graphic window is hidden.
o When the Edit menu changes, keyboard equivalents do not work untill
you open for the first time this menu in the new configuration.
o When a TEXT file is moved on the TopPred icon, it opens but
displays a lot of error messages since TopPred thinks that it is
a FOS and not a sequence.
Make me know any suggestions.
// \\ // \\ // \\ La cultura no es
Manuel G. CLAROS \': | \\ // | :,\\': | \\ un penoso dolor;
Ecole Normale Superieure \\ | | \\ // | | // \\ | | \\ es un gozoso
Genetique Moleculaire \\ | :,\\': | // \\ | :,\\ privilegio.
46 rue d'Ulm \\ // \\ // \\ // J. A.
75230 Paris Cedex 05 claros at biologie.ens.fr Vallejo-Nagera