IUBio GIL .. BIOSCI/Bionet News .. Biosequences .. Software .. FTP


Thu Mar 2 15:04:55 EST 1995

Unless it is something you have to do frequently, it is easy to estimate by 
hand, or if you want to get fancy, with a spreadsheet.  No estimate will be 
better than the pKs you assume for the titratable groups and these are subject 
to uncertainty. For starters, you could assume the following pKs, which come 
from measurements by Nozaki and Tanford, which I don't have the exact reference
for at hand):
alpha-COOH 3.4
D 3.9
E 4.3
H 6.5
alpha-NH3 7.6
C 8.5 (although they could be in SS bonds-you wouldn't know)
Y 9.9
K 10.3
R 12.5

Good luck, Bob

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