I thought this new tool might be of interest to this list. There is a free gene browser available from Bio::Neos, called GANT. It is a standalone application that lets you search for a gene and view the sequence, structure and annotation. The annotation is loaded from public data sources but the application is pluggable so as new plugins are developed for data sources you can just download the new plugin and view the annotation. There is also a primer picking capability that interfaces to an optimized Primer3 server. It is a nice interface for picking primers, you just click the sequence you want to amplify and select Pick Primers from the menu. It is fast also, you can design primers for a whole gene in less than a minute.
The software is free and can be downloaded from http://gant.bioneos.com.
Hope this is useful for some of you!