UGENE is free, open-source bioinformatics software. It has a friendly
user interface, runs on Linux, Windows, MacOS and Solaris, contains a
library of highly optimized algorithms, and has very moderate hardware
requirements to run.
This release includes:
Support for "cloning in silico". From now on, it is possible to
automatically digest sequences into fragments and construct new
molecules from defined fragments. This functionality is the first step
to fully support the cloning feature, which is one of the top requests
from UGENE users.
Brand new feature: Query Designer. This tool lets you analyze complex
signals in the DNA sequence using simple rules to set constraints for
algorithms. Check for more details in the corresponding documentation
HPC and GPGPU support: The Smith-Waterman algorithm now works using
OpenCL on both AMD and NVIDIA cards.
And much more...
Download link: http://ugene.unipro.ru/download.html