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EasyPCR and EasyPROBE uses integrated text, lessons, colorful graphics
and animated demonstrations to illustrate the basic concepts and
techniques of the Polymerase Chain Reaction (PCR) and DNA probes in a
highly interactive and entertaining format which makes those aspects
of Molecular Genetics learning easy and interesting. The programs were
prepared for science and medical students in their second year at
university taking their first course in Biochemistry and Genetics. The
first program, EasyPCR () gives emphasis on the PCR; special topics
include the basic methods such as the PCR reaction itself, cloning of
PCR products (termini repair reaction, ligation and transformation),
screening recombinant colonies by PCR and cycle-sequencing. The main
subject area of the second HyperCard program, namely EasyPROBE, is the
use of DNA probes in Molecular Genetics; in this software package,
special topics include the basic methods such as the restriction
endonucleases, electrophoresis, labelling and DNA probes, colony and
plaque hybridization, Southern and Northern blotting, Fluorescent in
situ Hybridization (FISH), cDNAs and DNA libraries. Both programs have
been written for the Apple Macintosh (System 6.0.7 and Finder 6.1.7 or
a newer version) with a color monitor using HyperCard 2.1 or greater
version and require at least 4 megabytes RAM; PC-Windows9s versions of
bots packages are also available.
Address for correspondence:
Bernard Aral, MD, Ph.D.
Laboratoire de Biochimie Genetique
CNRS URA1335 Faculte de Medecine Necker
156, Rue de Vaugirard 75730 Paris Cedex 15
France.
Tel. number: (331) 40615692
Fax number: (331) 40615690
E-Mail: URA1335 at citi2.fr
