DSC Protein Secondary Structure Prediction
I am pleased to announce the opening of a new web site for
the prediction of protein secondary structure.
Two prediction modes are available:
1) Given a single sequence. A multiple sequence alignmentt
will be formed and DSC used to predict secondary structure.
http://www.icnet.uk/bmm/dsc/dsc_form_align.html
2) Given a multiple sequence alignmnet. DSC will
use this alignment to predict secondary structure.
http://www.icnet.uk/bmm/dsc/dsc_read_align.html
The advantages of DSC are:
1) It is very accurate. DSC has a prediction accuracy of 70.1% on a
standard set of 126 proteins. This was not significantly different
from PHD, a popular prediction method. For medium length sequences
DSC was more accurate than PHD, and combining DSC and PHD produced
a prediction method more accurate than either.
2) It is free. There is no charge for using DSC.
3) The C source code is available. This would allow you
to run DSC on your own system if you had confidential sequences.
ftp://ftp.icnet.uk/icrf-public/bmm/king/dsc/dsc.tar.z
DSC is based on simple linear statistics. A paper on the
scientific basis of DSC will appear in Protein Science:
"Identification and Application of the Concepts Important for
Accurate and Reliable Protein Secondary Structure Prediction"
by Ross D. King & Michael J.E. Sternberg
Ross D. King
Biomolecular Modelling Laboratory
Imperial Cancer Research Fund
Lincoln's Inn Fields, P. O. Box 123,
London, WC2A 3PX, U.K.
Tel: +44 171 269 3565, Fax: +44 171 269 3479,
rd_king at icrf.icnet.uk
