Softberry Genome Explorer was enabled to provide visualization
of expression data in the context of annotated human genome.
http://softberry.com/
As an example, we maped major part of Unigen sequences used in analysis of
hereditary breast cancers and presented data from Hedenfalk et al. (The New
England Journal of Medicine, v 344, n 8, p.539-548).
In default window of
Genome Explorer, you can see fragment of human chromosome 1 with two genes,
first of which is iverexpressed in patients with BRCA1 mutation, the second
in patients with BRCA2 mutations.
These data are shown as an example of how
combining proprietary expression information with known genomic information
can dramatically speed up drug target identification (to see expression
data, go to graphical presentation of October, 2000 release of human genome,
point mouse to one of mapped brca genes, right click and select Show Expression)
http://softberry.com/genomb/chrvis.html.
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