In article <pgpmoose.200306021005.5415 at net.bio.net>,
Ernst-Ludwig Brust wrote:
> is there any Infoserver in www, where one can get
> Antigen Epitope AminoAcid-Sequences, the related
> Sequences of the variable Regions of the light and
> heavy Immunoglobulin-Chain and the RNA-Sequences of
> the two last.
You might try
http://www.ebi.ac.uk/imgt/
or other databases pointed to by
http://bioresearch.ac.uk/browse/mesh/detail/C0021027L0021027.html
The IMGT database does appear to have information about the
specificity of at least some of the immunoglobulins.
I'm not an immunoglobulin specialist, so I don't know whether the
information you are looking for is part of the standard annotation.
I think there may be some difficulty in providing epitope amino-acid
sequences, as the eptiope of an immunoglobulin is a 3D object, and may
contain amino acids that are close in 3-space but widely separated on
the backbone of the antigen. (That is, not all eptiopes can be
conveniently expressed as peptide sequences.)
--
Kevin Karplus karplus at soe.ucsc.eduhttp://www.soe.ucsc.edu/~karplus
Professor of Computer Engineering, University of California, Santa Cruz
Undergraduate and Graduate Director, Bioinformatics
Affiliations for identification only.
