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Epitope-Sequences and Related Immuoglobulin Variable Regions

Kevin Karplus karplus at bray.cse.ucsc.edu
Mon Jun 2 11:34:40 EST 2003

In article <pgpmoose.200306021005.5415 at net.bio.net>, 
Ernst-Ludwig Brust wrote: 
> is there any Infoserver in www, where one can get
> Antigen Epitope AminoAcid-Sequences, the related
> Sequences of the variable Regions of the light and
> heavy Immunoglobulin-Chain and the RNA-Sequences of
> the two last.

You might try
or other databases pointed to by 

The IMGT database does appear to have information about the
specificity of at least some of the immunoglobulins.
I'm not an immunoglobulin specialist, so I don't know whether the
information you are looking for is part of the standard annotation.

I think there may be some difficulty in providing epitope amino-acid
sequences, as the eptiope of an immunoglobulin is a 3D object, and may
contain amino acids that are close in 3-space but widely separated on
the backbone of the antigen. (That is, not all eptiopes can be
conveniently expressed as peptide sequences.)

Kevin Karplus 	karplus at soe.ucsc.edu	http://www.soe.ucsc.edu/~karplus
Professor of Computer Engineering, University of California, Santa Cruz
Undergraduate and Graduate Director, Bioinformatics
Affiliations for identification only.

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