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Mosaicism

Derek Tys dp_tys at postoffice.sandybay.utas.edu.au
Thu Jun 1 04:12:12 EST 1995


In article <Pine.SOL.3.91.950525132807.22342C-100000 at tin>, "Mr. C.G.
Sinclair" <csinclai at hgmp.mrc.ac.uk> wrote:

> On 16 May 1995, Wow24 wrote:
> 
> > Could anyone send me any kind of information regarding this genetic
> > disorder? I can only find very vague definitions of it, but no
> > manifestations or symptoms to look for. Please help!!!! Please!
> > 

Mosaicism also occurs in men with Klinefelter's Syndrome.  This karyotype
consists of 47,XXY usually; but can have many Xs followed by a Y.  For
Klinefelter's Syndrome to be considered Mosaic two cell lines has to
exist.  For example: 46,XY/ 47,XXY.  Klinefelter's are sterile, however a
mosaic may have normal reproductive cells (46,XY) and thus be able to
reproduce even if the rest of his body possesses the 47,XXY cells.


Derek Tys



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