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Lincoln Stein lstein at genome.wi.mit.edu
Wed Oct 4 21:26:48 EST 1995

                 DATA RELEASE 8 (SEPTEMBER 1995)

The eighth release of data from the Human Physical Mapping
Project at the Whitehead Institute/MIT Genome Center, covering data
generated through the end of September, 1995, is now available.

This data release contains YAC screening data for 11,871 sequence tagged
sites (STSs) screened on the CEPH mega-YAC library.  For each STS, we
report addresses for the YACs found to contain the STS. From the data
obtained so far, there are 677 contigs assembled using single
linkage between STSs.

In addition, we also report a radiation hybrid map of the genome
containing 5,138 STS markers mapped on the Genebridge Panel, as well
as integrations of the genetic, radiation hybrid and YAC contig

The data is available electronically in two ways.  

ANONYMOUS FTP: The entire data release is available as a set of
Microsoft Excel files and tab-delimited ascii files on our ftp
server.  Using an ftp client (such as "Fetch" on the Macintosh),
connect to 


Use "anonymous" as your user name, and give your e-mail address as your
password.  The data files are present in the directory 

The contents are as follows:

  09-95.INTRO.txt        Introduction to the data release, in straight text format
  09-95.INTRO.html       The same in HTML (World Wide Web) format
  09-95.STS2YAC.txt      STS & YAC screening data as tab-delimited text.
  09-95.STS2YAC.sea.hqx  The same as a compressed Microsoft Excel File
  chromosomes/           The same, split into smaller chromosome-specific files
  09-95.YAC2STS.txt      Inverse map of YAC to STS screening data
  09-95.CONTIG2STS.txt   YAC contig lists.
  09-95.CONTIG2STS.txt   The same, inverted.
  09-95.sequence.txt     Full sequences of STSs developed in-house.
  rhmap/                 Radiation hybrid maps.

THE WORLD-WIDE WEB: You will need a World Wide Web client such as
Mosaic (Unix, MS-Windows and Macintosh) or MacWeb (Macintosh). 
Instruct your client to connect to 


>From there, follow the "Human Physical Mapping Project" link.  You will be
able to browse and download the raw data set, view the individual and
integrated maps, and to get information on the radiation hybrid and
contig analyses.

A subset of the STSs (those for which we have chromosomal assignments)
are also available through the Genome Database (GDB).  All STSs are
also submitted to GenBank.

QUESTIONS AND PROBLEMS.  If users have any questions or problems,
please contact us at human_STS_help at genome.wi.mit.edu We invite
suggestions about how to make these data release most useful.

DATA RELEASE POLICY AND CITATION.  Data releases are scheduled monthly.
At the end of each month, all genomic mapping
data are reviewed and prepared for distribution via CGR's electronic
databases.  Data releases typically occur within a week of the
close of the month. Releases are announced by electronic messages 
posted to the following two newsgroups: "bionet.genome.chromosomes" and

CGR's data release policy aims to ensure that scientific colleagues
have immediate access to information that may assist them in the
search for genes. Data releases do not constitute scientific
publication of CGR's work, but rather provide scientists with a
regular look into our lab notebooks.   For projects aimed at the
analysis of particular genes or subchromosomal regions, permission is
hereby granted to use our data without the need for a formal
collaboration, subject only to appropriate acknowledgment.   For
projects aimed at large-scale mapping of entire chromosomes or entire
genomes, use of the data and markers should be on a collaborative

The information for the human genome mapping project should be cited
as: Whitehead Institute/MIT Center for Genome Research, Human Physical
Mapping Project, Data Release 8 (September 1995).

Lincoln D. Stein                Whitehead Institute/MIT Genome Center
lstein at genome.wi.mit.edu	Cambridge, MA 02142

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