>>>>August 22, 1996
>>>> A Postdoctoral Research Associate position is currently available in my
>laboratory to participate in NIH-funded studies on mechanisms of locus control
>region function and erythroid-specific gene transcription. Questions being
>investigated include - how is the human b-globin lcr shared by multiple
>promoters on a chromosome, what are the requirements for long-range gene
>activation by lcrs, and do the protein components of the lcr form ordered
>nucleoprotein complexes?
>> A second project focuses on the TAL1 protein, an erythroid-specific
>transcription factor and a crucial regulator of mammalian development. The
>regulatory regions of the TAL1 gene are disrupted by a chromosomal deletion in
>patients with acute T cell lymphocytic leukemia. This deletion results in
>ectopic expression of TAL1 in T cells, and thus may be directly involved in
>leukemogenesis. One aim is to delineate the cis-acting elements and
>trans-acting factors which drive TAL1 transcription in erythroid and T cells.
>A second aim focuses on identifying target genes for TAL1.
>> Potential applicants should submit a brief description of research
>interests, a curriculum vitae, and the names of three individuals for
>recommendations to:
>>>>Emery H. Bresnick, Ph.D.
>University of Wisconsin-Madison
>Department of Pharmacology
>387 Medical Science
>1300 University Avenue
>Madison, WI 53706
>>TEL. (608) 265-6446
>E-Mail - ehbresni at facstaff.wisc.edu
