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human 2-3 translocation

Michael Anthony Lynch d8950093 at mail.connect.usq.edu.au
Fri Oct 30 23:36:06 EST 1998


where can a get the book genetic time bomb.

Hank Burr wrote:

> I have a friend caring for a 9 year old girl who has a 2-3 reciprocal
> translocation;  the long arm of 2 is swapped with the short arm of 3.
>
> The natural mother has not been diagnosed, but has, however, produced 2
> girls and one boy, by two fathers;  all the children have the
> translocation.  The mother is phenotypically normal, while the 9 year old
> daughter exhibits mental slowness, and has been diagnosed as having
> Wolfe-Parkinson-White heart syndrome.  She also has a very broad nose
> bridge.  The other two children are very young, and have not shown any
> unusual characteristics yet.  My first guess as to original translocation
> event would be during embryogenesis of the mother's germ line cells.
>
> I would greatly appreciate information on:
>         1.  The heart syndrome
>         2.  2-3 translocations - their frequency and phenotypic consequences
>         3.  Related literature references
>         4.  Your thoughts on the initial (original, in this family) translocation
> event
>
> I am comfortable with scientific jargon and slang associated with this
> topic, having once been a practicing professional in the field of DNA and
> genome evolution, and recombination at the molecular level.
>
> Thank you,
>
> Hank Burr
> hburr at ohiohills.com






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