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Hank Burr wrote:
> I have a friend caring for a 9 year old girl who has a 2-3 reciprocal
> translocation; the long arm of 2 is swapped with the short arm of 3.
>> The natural mother has not been diagnosed, but has, however, produced 2
> girls and one boy, by two fathers; all the children have the
> translocation. The mother is phenotypically normal, while the 9 year old
> daughter exhibits mental slowness, and has been diagnosed as having
> Wolfe-Parkinson-White heart syndrome. She also has a very broad nose
> bridge. The other two children are very young, and have not shown any
> unusual characteristics yet. My first guess as to original translocation
> event would be during embryogenesis of the mother's germ line cells.
>> I would greatly appreciate information on:
> 1. The heart syndrome
> 2. 2-3 translocations - their frequency and phenotypic consequences
> 3. Related literature references
> 4. Your thoughts on the initial (original, in this family) translocation
>> I am comfortable with scientific jargon and slang associated with this
> topic, having once been a practicing professional in the field of DNA and
> genome evolution, and recombination at the molecular level.
>> Thank you,
>> Hank Burr
>hburr at ohiohills.com