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Biofilm and Catheters

Ryan Jordan ryan_j at erc.montana.edu
Sun Jun 22 09:02:49 EST 2003

 > Are there any antibiotics that have shown to be somewhat successful in
 > penetrating or destroying Biofilm? I am interested in finding studies
 > have been or are in progress addressing Biofilm distruction and
 > catheters.

Hi John: When we've looked at central venous catheters, stents, etc.
with S. epi and S. aureus biofilms, we've found cipro and vanco to be
reasonable for penetrating the biofilm; however, they still seem to
leave a persister population that has a tendency to reseed the biofilm.
Our recommended strategy has not been to find a magic anti-biofilm
antibiotic so to speak (that would be nice, and they are in development,
but it'll probably be awhile before they become FDA approved), but to
design a dosing strategy to deal with the persisters.

Best Regards,

Ryan Jordan
Biofilm science training online at:


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