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strange patterns of inheritance

Peter Hunt phunt at chiswick.anprod.CSIRO.AU
Tue Mar 21 21:23:53 EST 1995

Dear Worm Breeders,

Please consider this hypothetical situation:

Homozygotes for a mutation at X-linked locus (call it any) have a
particular phenotype which is 100% penetrant in all selfed progeny.  BUT if
you take hemizygous males and cross them with homozygous hermaphrodites
then the phenotype of the resultant progeny is not 100% penetrant.
So 100% of any/any animals which are self progeny have the mutant phenotype
BUT <100% (say 80%) any/any animals which are the progeny of a cross
between any/o males and any/any hermaphrodites have the mutant phenotype.

What do you check to make sure that this result is real? (apart from
checking that your parental strains are what you think they are).

If it is real, then what are the possible explanations?

Has anyone actually seen this (or something similar occur)?

Any comments would be appreciated.



  ^^             Peter Hunt
  ##             UNE Dept. Biochemistry/ CSIRO Div. Animal Health
  __             AUSTRALIA

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