POSTDOCTORAL OR VISITING SCIENTIST RESEARCH PROJECT
RESEARCH ON APPLYING MODE OF ACTION DATA FOR COMBINING
RISKS FOR DEVELOPMENTAL TOXICOLOGY
Applications are sought for a postdoctoral fellow or
visiting scientist to participate in ongoing studies aimed at
understanding the fundamental mechanisms of abnormal
development and developing biomarkers and models of
mechanism-based dose-response relationships for combining
risks in developmental toxicology. The research involves
exploring biochemical and pathological approaches to
segmentation anomalies and subsequent axial skeletal defects.
Recent advances in molecular and cellular approaches to
understanding the process of segmentation and regulatory
genes involved makes this a potentially fruitful area of study.
This research is being extended to the study of specific
chemical agents and combinations of chemicals for the
purpose of using mechanism/mode of action to understand
interactions and predict risks.
The ideal candidate is a recent graduate (0-6 years
postdoctoral) with a strong background in molecular
developmental biology/toxicology and a demonstrated interest
in the application of such techniques to problems in
developmental toxicology. Experience with studies on normal
and altered segmentation will be helpful. Technical expertise in
procedures at the molecular level which will support
mechanistic studies of altered development following
exposure to various agents is required. In particular, studies
on the genetic control of segmentation, the role of stress
proteins, the cell cycle and apoptotic pathways are of interest.
The candidate should also have an interest in applying
information from molecular studies to the level of the whole
embryo and to the dynamic processes that occur during
This research project is supported by the U.S.
Environmental Protection Agency and the U.S. Food and Drug
Administration through the FDA Postgraduate Research
Program at CDRH. The program is administered by the Oak
Ridge Institute for Science and Education (ORISE) which
processes applications and makes awards. Applicants do not
have to be U.S. citizens, but must have good English reading and
writing skills. The position is available beginning October 1,
1999. The research will be done at the FDA Center for Devices
and Radiological Health laboratory in Rockville, MD. For further
information, please contact Dr. Carole Kimmel (tel: 202-564-3307;
fax: 202-565-0078; email: kimmel.carole at epa.gov) or Dr. Gary
Kimmel (tel: 202-564-3308; fax: 202-565-0078; email:
kimmel.gary at epa.gov), National Center for Environmental
Assessment-Washington Office (8623D), U.S. Environmental
Protection Agency, SW, Washington, DC 20460.