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Post-doc position: innate immunity

Jonathan Ewbank ewbank at ciml.univ-mrs.fr
Wed May 19 15:36:35 EST 1999

****This post is open only to non-French nationals****

A two-year post-doctoral position is available in my lab to study various
aspects of innate immunity using C. elegans as a model. This research is
funded by INSERM, the CNRS and the French Ministry of Education and Research.

Among the projects are:

i. A collaboration with the group of Jules Hoffmann, using MALDI TOF mass
spectrometry to identify anti-microbial peptides induced upon infection of
C. elegans. This approach has been applied successfully by his group to
identify anti-microbial peptides in Drosophila (PNAS 1998 95:11342; J
Protein Chem. 1998 17:528). Such peptides are potential antibiotics for

ii. Using 2D electrophoresis and mass spectrometry to identify C. elegans
proteins involved in host reponse to infection.

iii. A collaboration with the group of Brett Finlay, on bacterial virulence
factors (see his recent review in Cell 1999 96:315).

For these projects, identification of the corresponding genes (made facile
by the existence of the genome sequence) will be the first step in the
molecular dissection of the relevant intracellular pathways. Therefore the
ideal candidate, as well as having a strong publication record, will have
had several years' experience with C. elegans molecular genetics,
preferably with a background also in biochemistry. As my own research
background is relatively diverse (e.g. Ewbank and Creighton, Nature 1991
350:518; Ewbank et al., Science 1997 275:980), I welcome applications from
any motivated individuals.
Please send a CV with the names of three referees to the e-mail address below.
An understanding of French is not required.

I shall be attending the meeting at Madison and would welcome informal

Jonathan Ewbank

Centre d'Immunologie de Marseille-Luminy,
163 Avenue de Luminy,
Case 906,
13288 Marseille Cedex 9,

ewbank at ciml.univ-mrs.fr

Tel: +33 491 269 466 en France: 04 91 26 94 66
Fax: +33 491 269 430 en France: 04 91 26 94 66

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