Biology of Ageing in C. elegans and Drosophila
Six postdoctoral, two technical positions available at University College
London
A new 5 year co-ordinated programme has been awarded by the Wellcome Trust
within the Functional Genomics Initiative. Commencing in October 2002, its
aim is to understand the biological basis of the ageing process. Building
upon studies of dietary restriction, free radical biology, and the recent
discovery of an insulin-like signalling system controlling longevity in C.
elegans and Drosophila melanogaster, and possibly mice, the project will
combine investigation of the fully sequenced genomes of model organisms,
with the search for common determinants of ageing in worms and flies, to
identify and test determinants of ageing in mice. This research consortium
is co-ordinated by Prof. Linda Partridge (UCL) and involves the
laboratories of Dr Martin Brand (MRC Dunn Human Nutrition Unit, Cambridge),
Dr David Gems (UCL), Dr Sally Leevers (Cancer Research UK), Prof. Janet
Thornton (European Bioinformatics Institute, Hinxton, Cambridge), and Dr
Dominic Withers (Imperial College, London).
This will be one of the largest, and most ambitious projects ever
undertaken in Europe to identify the biological determinants of ageing. We
invite highly motivated, well-trained and experienced researchers to join
this exciting project.
Ageing in C. elegans (Gems). Two postdoc positions: (1) Reverse genetic
analysis of signalling genes modulating ageing. Applicants should have
skills in molecular genetics and microscopy. (2) Ageing and gene
expression. Applicants should have skills in molecular biology,
bioinformatics and a good grasp of statistics. Experience with microarray
analysis an advantage. Technician grade I: Senior Laboratory Manager.
Seeking an exceptional individual with skills in classical and molecular
genetics and microscopy. In all cases, experience with C. elegans an
advantage.
Ageing in Drosophila (Partridge and Leevers): Four postdoc positions: (1,2)
Analysis of signalling genes controlling development and ageing. Will
include targeted mutagenesis and manipulation of expression of genes
involved in neuroendocrine regulation of ageing. (3) Analysis of global
changes in gene expression resulting from treatments that retard ageing.
Knowledge of bioinformatics and a good grasp of statistics essential.
Experience with microarray analysis recommended. (4) Ageing, mitochondrial
function, and free radical biology. Applicant should have experience in
biochemistry. Technician grade G, laboratory manager and research
technician. All applicants should have experience of classical and
molecular genetics; experience with Drosophila an advantage. E-mail:
L.Partridge at ucl.ac.uk, leevers at cancer.org.uk
All posts are initially for 3 years. Starting salaries: level 2 postdocs,
up to =A327,589, or 44,310 EUR, $38,660 according to experience. Technicians=
,
grade G: =A325,391 (41,070 EUR, $36,980); grade I, =A329,073 (47,020 EUR,
$42,340). Salaries include London allowance. Applicants should send a CV
and contact information for 3 referees to:
David Gems, Dept of Biology, University College London, Gower St., London
WC1E 6BT, UK.
Tel: +44 (0) 20 7679 4381.
E-mail: david.gems at ucl.ac.uk
URL: www.gene.ucl.ac.uk/nematode
=46or further information see www.gene.ucl.ac.uk/nematode/WTFG.html
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