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Post-doc and technician positions at UPenn

Meera Sundaram sundaram at mail.med.upenn.edu
Thu Nov 21 18:18:13 EST 2002

Post-doctoral and research technician positions are available to 
adapt molecular genetic tools such as RNAi and transgenesis which are 
standard in C. elegans for use in the parasitic helminths 
Strongyloides stercoralis or Schistosoma mansoni.  Post-docs will be 
free to choose the types of genes they wish to target and biological 
questions they wish to pursue - this is a wide open field!  Side 
projects involving other aspects of C. elegans, St. stercoralis or S. 
mansoni biology are also available.  Individuals with prior 
experience in either C. elegans or parasitic helminth systems are 
particularly encouraged to apply.

Despite the impact of helminth parasites on human and animal health, 
there are no vaccines against these agents and resistance threatens a 
dwindling armamentarium of safe and effective anthelmintic drugs. 
Modern methods that have been used to identify and characterize 
molecular targets for rational drug and vaccine development in other 
disease systems, and which could be used for basic molecular and 
cellular biological study, are currently lacking for the parasitic 
helminths.  On the other hand, descriptive genomics for important 
helminth parasites is a relatively rapidly developing field. With 
support from the Ellison Medical Foundation, we are developing 
experimental tools that would allow these growing databases to be 
exploited for functional study. 

Interested individuals should send a cover letter, CV and names of 
three references to one of the researchers below.

Dr. Meera Sundaram's primary interest is in the regulation of the ras 
signal transduction pathway during cell differentiation and 
organogenesis.  Her studies employ vulva development in C. elegans as 
a model system.  Dept. of Genetics, UPenn School of Medicine, 
Philadelphia PA 19104.  email: sundaram at mail.med.upenn.edu

Dr. James Lok's long-standing interest has been the developmental 
biology of filariae and other parasitic nematodes.  Recently, his lab 
has turned its attention to the possibility that homologs of genes 
regulating dauer development in C. elegans, the so-called daf genes, 
also control development of infective parasitic nematode larvae. 
This work has prompted a shift to Strongyloides stercoralis as an 
experimental model.  Dept. of Pathobiology, UPenn School of 
Veterinary Medicine, Philadelphia PA 19104. email: jlok at vet.upenn.edu

Dr. Edward Pearce is interested in the molecular basis of 
schistosome/host interactions, and in the immunology of 
schistosomiasis.  Work from his laboratory has characterized genes 
encoding elements of a TGFb signaling pathway in S. mansoni.  Dept. 
of Pathobiology, UPenn School of Veterinary Medicine, Philadelphia PA 
19104. email: ejpearce at mail.med.upenn.edu

Meera Sundaram, Ph.D.
Dept. of Genetics
UPenn School of Medicine
709A Stellar-Chance Building
422 Curie Blvd.
Philadelphia, PA 19104-6100

215-573-4527 (office phone)
215-573-9411 (FAX)

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