This short mail to inform the worm community of the availability of=20
GOToolBox, a series of programs using Gene ontology that we published=20
recently in Genome biology=20
GOToolBox can be useful to analyse groups of genes derived from=20
microarrays,Chromatin-Immunoprecipitations, from the analysis of=20
protein-protein (two-hybrid), protein_DNA and/or genetic networks, ....
The programs from GOToolBox are directly accessible through a Web site=20=
described in the article.
GOToolBox performs five main tasks:
- gene dataset creation,
- selection and fitting of GO terms at a given ontology level (GO-Diet),
- statistical analysis of GO terms associated with gene sets (GO-Stats)=20=
in order to find over- or under-represented terms,
- GO-based gene clustering (GO-Proxy) allowing to find sub-groups of=20
functionnally related genes within a gene set,
- gene retrieval based on GO annotation similarity (GO-Family) in one=20
or several species.
Other developments are presently on their way.
At the moment, GOToolBox supports analyses of GO terms for six species :
Yeast (Sc), Arabidopsis, Drosophila, nematode, mouse and humans.
For the authors,
David Martin and Bernard Jacq
Parc Scientifique de luminy
13288 Marseille Cedex 9
tel (33) 04 91 82 94 25
fax (33) 04 91 82 06 82
Apr=E9s les Etats g=E9n=E9raux de la Recherche
de GRENOBLE, continuez =E0 d=E9fendre la recherche=20
Petition for a new and ambitious European science policy:=20