Good days, everybody ,
I have a question :
Why there is not transgenic pigs expressing human CR1 to Overcome
hyperacute xenograft rejection ?
CR1 has extrinsic activity , i.e., it inactivates convertases assembled
membranes, and it also exhibits intrinsic activity ,i.e., it inactivates
formed on the same membrane on which it is expressed. Among the members
of the RCA
family , CR1 is the only one that possesses dcay-accelerating activity
for both C3 and
C5 convertases in both the classical and alternative pathways,as well as
cofactor activity for the degradation of both C3b and C4b .
Would you please send me the plasmid containing the sequence for CR1 ?
Department of immunology
The Third Military Medical University
Gao tanyan,Sha pingba
Chongqing , 400038
People's Republic of China.
E-mail: immuno06 at mail.tmmu.com.cn