Has anybody produced a mouse knock-in using GFP as a reporter?
In other words, has any group replaced the open reading frame of a gene
with the GFP open reading frame, so that a mouse would result in which GFP
expression would reflect the activation of that gene's regulatory
elements? Would work when the knock-in is heterozygous, so that the loss
of that gene's ORF would probably not result in a significant phenotype.