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Sialic acid linkages

Steven Pirie-Shepherd srps at galactose.mc.duke.edu
Mon Feb 27 10:37:32 EST 1995


Dear Anyone,

I am working with a protein which has sialic acid on O-linked Thr glycan 
(classic NAcAl-Gal 2-3SA
                |
               2-6SA
 My question is this...does poly sialic acid have to be in the 2-8 
linkage, what is the linkage to, and which amino acid is involved? Can 
the sialic acid form a 2-3 chain? or a 2-6 chain?, can you get 
polysialylation on the classic O-linked glycan?
Thanx


__________________________________________________
Steven Pirie-Shepherd		       		
srps at galactose.mc.duke.edu	        
"Insert your own pithy phrase just about here!"



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