Succinylation will yield a dimer, monovalent forms have been produced by
using a covalent derivatization with an active-site target.
This was well worked out in the early 70's. Hit MEDLINE and search
under author names John Wang and Bruce Cunningham; I think it was published
in the Journal of Biological Chemistry.
If you don't want functional monomer, you can of course denature, but I
assume that is not what you want.
In Article <43v2cu$iah at mserv1.dl.ac.uk>, Barry Hardy
<bhardy at convex.ox.ac.uk> wrote:
>>Does anyone know whether Concanavalin A exists as a monomer under very
>Someone may have mutated Con A and allowed the naturally occurring
>tretramer to fall apart.