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known ConA binding proteins

David Ashford da5 at york.ac.uk
Tue Sep 24 05:29:32 EST 1996

Dear John,

To address your last question first; Con A will bind to any glycoprotein as 
long as it carries appropriate glycans. The specificity of Con A is to 
alpha-linked mannose residues so it will bind strongly to oligomannose and 
hybrid type glycans. HRP is not a good example. In order to predict what 
'proteins' Con A will bind requires a knowledge of the glycosylation of the 
protein. In a given cell I would expect that many different glycoproteins 
will carry the necessary structures for binding to Con A.   

As to a list of Con A binding glycoproteins, I don't know if one has been 
collated recently. Pharmacia used to keep a bibliography of applications 
for Con A-Sepharose, you could try them. Alternatively, you could look back 
at reviews on lectins for information and as possible sources of 
references. Try Lis & Sharon (1973) Ann.Rev.Biochem. 42, 541-574 or 
Goldstein & Hayes (1978) Adv.Carb.Chem.Biochem. 35, 127-340. Also there's a 
book on lectins "The Lectins. Properties, Functions, and Applications in 
Biology and Medicine." Eds. Liener, Sharon & Golstein, Academic Press, 

Good hunting,

   Dr David A. Ashford                                                  
   Plant Glycoprotein Research Facility                                 
   The Plant Laboratory                                                 
   Department of Biology                                                
   University of York                         Tel: (44)(0)1904 434391   
   P.O. Box 373                               Fax: (44)(0)1904 434312   
   York  YO1 5YW                              Email:  da5 at york.ac.uk    

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