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A Maize Genetic Question

Lisa Harper ligule at nature.berkeley.edu
Mon May 1 21:31:03 EST 2000

Here is a genetic mystery (to me at least),
	I now know of two cases where individual researchers have
identified an SSR within 1-2 cM of their gene of interest.  These closely
linked SSRs were identified in progeny of a self following an outcross to
B73.  Upon repetitive backcrossing to B73, the SSR gets genetically farther
and farther away; in one case going from 1 cM to ~25cM in one generation-
statistically significant with a chi-squared test.  What is happening here?
Have people who use marker-assisted breeding seen this?  At first, I
thought it was a mistake, but with two independent cases, and all numbers
checked for statistical significance, I think it is real.  Do rates of
recombination change with increased homozygosity (a hard thing to measure)?
	Thank you for your help!
Lisa Harper
Cande Lab
Department of Molecular and Cell Biology
345 LSA
University of California
Berkeley, CA 94720-3200

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