Dear Modelers,
This may be laughable, but I need to know. Can one construct a model protein
structure from scratch? If one has a protein of a few hundred amino acids
length and various types of data (homology, site-directed mutagenesis,
photolabelling, etc), and can come up with a hypothetical super-secondary or
tertiary structure on paper for most or part of it, is it possible to constuct
the model in a program that can then display it and be used for further
refinement? I have been trying to do this in Hyperchem, with much frustration
since I can't fold the polypeptide about very well once I've made it. Is there
a way, or am I just trying to do something impossible? All advice greatly
appreciated!
Frank van de Loo
USDA/ARS, University of Kentucky.
