Kaspar Hauser MD (95mhn at williams.edu) wrote:
: Hello,
: Does anyone have any experience producing a very crude
: structural hypothesis from sequence data? We have Sybyl, but I've
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: I've tried Sybyls built in structure-seq database, and constructed my
: own database with many similar proteins and just the resolved protein
: with homology. Any suggestions or references would be appreciated,
: Max Nanao
:95mhn at cc.williams.edu:nanao at ochre.mgh.harvard.edu
Kaspar,
Why not just directly substitute each residue [i.e. 'mutate' in Sybyl]
in your protein of know structure for the residue in your target? If
your target has 85% sequence similarity, this seems like a reasonable
thing to do. Any other readers have comments about the validity of this?
Andy Sheppard
mbasd at seqnet.dl.ac.uk
