Dear Readers,
I would be grateful for comments, ideas, anecdotes, references etc. on the
following topic:
In the area of drug research, a frequent problem which arises is that of
obtaining oral-availability: it is usually more desirable to have an orally
active compound than one which is active only when injected.
What I want to know is the following:
1 Is it possible to predict whether a compound will be orally active?
2 On observing a compound has little or no oral activity, are there any
structural modifications which can be used to increase the oral activity
of the compound?
3 Is it possible to use an adjuvant to increase the absorption of a
weakly orally active compound?
4 Are there any in vitro test systems which will predict whether a
compound is orally active? If there are such test systems, are they
available commercially or have they been devloped in-house?
I will summarise useful information to the net.
Andy Sheppard
Ferring Research Institute
mbasd at seqnet.dl.ac.uk
[crossposted to newsgroups bionet.general, bionet.molbio.methds-reagnts,
bionet.molec-model and the Computational Chemistry list]
