There are many companies investigating small molecule drug interactions.
Among these are Genentech (gene.com), Roche Molecular Systems
(roche.com), Bayer Pharmaceutical (510) 705-5000 front desk, Arris
Pharmaceutical (arris.com) "...receptor-based discovery programs designed
to identify small molecule drugs...", Terrapin Technologies previous work
with GST inhibitors using molecular modeling (415) 244-9303, Onyx
(onyx.com), Protein Design Lab (pdl.com), and Molecular Research
Institute (415) 424 9924. An article in J. Med. Chem. 1994, 37, 189-194
Isozyme-Specific Glutathione-S-Transferase Inhibitors:Design and
Synthesis written by Lyttle, M.H., Hocker, M.D., Hui C.H. etal describes
a strategy for studying drug protein interactions.
