Our recent program ProAnWin, Protein Analyst
for Windows 3.11/95, is now available at
iubio.bio.indiana.edu, in directory /molbio/ibmpc/ as paw.exe.
Access to iubio by ftp, http, and gopher methods are supported.
ProAnWin is an application for multiple protein sequence alignment
(automatic and manual), comparative sequence analysis, studying
protein structure-activity (genotype - phenotype) relationships
and designing site-directed mutagenesis (with 3D structire viewer).
The program does:
input of sequences from several formats (SWISS-PROT, PIR, FASTA, GCG,
CLUSTAL) and 3D structure in PDB format; flexible multiple protein
sequences alignment and threading sequences into known 3D structure
(ClustalV + manual alignment); input of user-defined protein
activities, properties or related phenotypes (with possibility to
transform activity: log(x), 1/x, etc.); calculation of many
characteristics (hydrophobicity, amphipathicity, etc.) of linear and
spatial protein sites; fast multiple linear regression analysis of
structure-activity relationships (up to eight independent factors);
activity prediction for untested or mutated proteins; data
visualization (regression plots, 3D structures with sites highlighted,
multiple alignments); displaying found sites on sequences and 3D
structure.
The program can be applied to analysis of various protein-related
biological data, to prediction of activity (phenotype) of newly
sequenced proteins and to simulation of protein-engineering
experiments.
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Alexey Eroshkin Research Institute of Molecular Biology
E.mail: eroshkin at vector.nsk.su State Research Center of Virology and
Tel: +7 (3832) - 647774 Biotechnology "Vector"
Fax: +7 (3832) - 328831 Koltsovo, Novosibirsk Region
633159 Russia
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