In article <5fm049$o3 at rc1.vub.ac.be>,
ldewit at ben.vub.ac.be (Dimitri Harmegnies) wrote:
>Does anybody could explain me the principle of homology modelling (for
>example, wich percent of sequence homology is considered as sufficient
>to suppose a structural homology ?)
100% do not suffice. The same protein (100% sequence homology) may
offer various conformations with poor 3D-structural homology.
I do not know if the reverse exists or not: high percentage of 3D
homology but low percentage of sequence homology.
Michel Petitjean, Email: petitjean at itodys.jussieu.fr
ITODYS (CNRS, URA34) ptitjean at ccr.jussieu.fr