Dear experts:
I have a protein homology modeling work at hand. This protein can be
divided into 2 lobes, N terminal lobe and C terminal lobe, and the 2
lobes are connected by a short loop sequence. Comparing the structures of
the templates, I found that the overall superimposion of the whole
proteins is not good. But if I seperately superimposed the N lobe or C
lobe, the superimposion is good. So I plan to do a model by seperately
modeling the N lobe and C lobe and then connecting the 2 lobes by loop.
I used different run to separately model the N and C lobe. My question
is that how to combine the two run in a single running so that I can do
the loop modeling?
Any comment/suggestion/help will be great appreciated. Thank you very
much.
Sincerely your
ccchuang
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Chyh-Chong Chuang
Institude of Biological Chemistry,
Academia Sinica,Taipei, Taiwan
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Phone: 886-2-7858981 ext 7091
Fax: 886-2-7883473
E-Mail: ccchuang at gate.sinica.edu.tw
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