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Tripos's Composer! How to seperately model 2 lobes in a protein?

Chyh-chong Chuang ccchuang at GATE.SINICA.EDU.TW
Wed May 14 01:58:35 EST 1997

 Dear experts:
  I have a protein homology modeling work at hand. This protein can be 
 divided into 2 lobes, N terminal lobe and C terminal lobe, and the 2 
 lobes are connected by a short loop sequence. Comparing the structures of 
 the templates, I found that the overall superimposion of the whole 
 proteins is not good. But if I seperately superimposed the N lobe or C 
 lobe, the superimposion is good. So I plan to do a model by seperately 
 modeling the N lobe and C lobe and then connecting the 2 lobes by loop. 
 I used different run to separately model the N and C lobe. My question 
 is that how to combine the two run in a single running so that I can do 
 the loop modeling? 
  Any comment/suggestion/help will be great appreciated. Thank you very 
 Sincerely your

    Chyh-Chong Chuang
    Institude of Biological Chemistry, 
    Academia Sinica,Taipei, Taiwan
    Phone: 886-2-7858981 ext 7091 
    Fax: 886-2-7883473
    E-Mail: ccchuang at gate.sinica.edu.tw

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