Graduate student positions available
Three graduate student positions are available within the NMR spectroscopy
department of the Bijvoet Center for Biomolecular Research at Utrecht
University.
The research of the Utrecht NMR group deals with problems in biochemistry and
molecular biology studied by the method of high-resolution NMR spectroscopy.
The group also contributes to the development of NMR methodology. A major theme
is that of the regulation of gene expression with aspects of both protein-
nucleic acid interaction and protein-protein interaction. These interactions
are studied in bacterial repressors, eukaryotic transcription factors and
initiation factors involved in protein biosynthesis. The aim is to understand
these biomolecular recognition processes in terms of detailed three-dimensional
structures and dynamics. With respect to NMR methodology, novel NMR experiments
and methods for structure refinement and for the quality assessment of protein
NMR structures are being developed in the group.
The NMR infrastructure at the Bijvoet Center is excellent with NMR spectrometers
covering the range from 300 to 750 MHz (funding for a 900 MHz spectrometer has
been approved) and state of the art computers and laboratory facilities for
cloning and protein expression.
The Ph.D. positions are for a period of four years. Possible research projects
are:
- NMR structural studies of DNA-binding repair enzymes
- development and application of fast protocols for NMR structure determination
toward structure-based functional genomics
- Protein-DNA interaction of retinoic acids receptors
For additional information contact:
Prof. Dr. R. Kaptein kaptein at nmr.chem.uu.nl
Prof. Dr. R. Boelens boelens at nmr.chem.uu.nl
Dr. A.M.J.J. Bonvin abonvin at nmr.chem.uu.nl
Contact address:
Bijvoet Center for Biomolecular Research
Department of NMR Spectroscopy
Padualaan 8, 3584 CH Utrecht, the Netherlands
Phone: +31-30-2532652, fax: +31-30-2537623
http://www.nmr.chem.uu.nl
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| Dr. Alexandre Bonvin | Phone: Int+31-30-2533859 |
| NMR, Utrecht University | Fax: Int+31-30-2537623 |
| Padualaan 8, 3584 CH Utrecht | Email: abonvin at nmr.chem.uu.nl |
| The Netherlands | http://www-nmr.chem.uu.nl/~abonvin |
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