Two positions are available immediately for highly motivated
individuals with Bsc or MS.c. degrees to work on one of several
research areas currently in progress in my laboratory. S/he can
work on he characterization of a novel membrane protein which we
have recently identified to be overexpressed in multidrug resistant
breast cancer cells. Other projects related to multidrug resistance
in ca cer cells involve the molecular characterization of
P-glycoprotein drug binding and reversal. P-glycoprotein has been
previously identified to be important in the expression of the
multidrug resist nce phenotype in certain cancers. The second area of
research relates to the multidrug resistance in malaria. Unpublished
work in this laboratory has led to the development of drug resistant
clones f Plasmodium falciparum. Preliminary characterization of
these drug resistant clones of Plasmodium falciparum suggests a role
for an ATP drug efflux pump. Work is in progress to clone the gene
respo sible for this multidrug resistance phenotype. Finally, we are
interested in developing proteolytic abzymes or catalytic monoclonal
antibodies which can cleave amide bonds in peptides and proteins t
specific sites. This project is done in collaboration with another
group of medicinal chemists. Research in the above projects employ
several molecular techniques (hybridoma technology, membrane b
ochemistry, malaria tissue culture, molecular biology and PCR,
peptide chemistry and synthesis, and some organic chemistry) in a
well equipped laboratory (several HPLC systems, automated peptide
syn hesizer, PCR machine, Single cell fluorescence microscopy etc.)
Interested individuals should get in touch with Dr. E. Georges at the
Institute of Parasitology, McGill University. Email address. ELIAS at PARASIT.lan.McGill.ca
