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lung regeneration

Pietsch, Paul A. pietsch at indiana.edu
Thu Oct 28 21:13:46 EST 2004

Paul Weiss conducted some experiments in 1927 in which his point of
departure was that amphibian lungs don't regenerate.  He turned lungs
inside out and slid them onto skinned limbs; amputation stimulated
regeneration.  The regenerates had a corium. The regenerate's corium,
Weiss concluded, was produced from the blastema, not the coruim in the
stump -- since the stump didn't have a coruum and, he assumed, lungs
don't regenerate.

Anyway, back in the 1950's, I tried unsuccessfully to find evidence for
or against Weiss's underlying assumption.   Vorontsova and Liosner
notwithstanding, I'm still looking.

Here's the Weiss reference (sans accents):

Weiss, P.  Die Herkunft der Haut in Extremitatenregenerat (Versuche mit
Hautprothesesen aus Lunge bei Triton cristatus). Roux's Archiv.

If you ever find a definitive answer, please let me know about it.  
Paul Pietsch

-----Original Message-----
From: owner-urodeles at hgmp.mrc.ac.uk
[mailto:owner-urodeles at hgmp.mrc.ac.uk] On Behalf Of Richard Gordon
Sent: Saturday, October 16, 2004 9:15 AM
To: bionet-organisms-urodeles at net.bio.net
Subject: lung regeneration

This is a follow up to the discussion copied below. I'd appreciate 
any explicit and/or more recent references to lung regeneration, 
especially in urodeles such as the axolotl? Thanks.
Yours, -Dick Gordon

From: "Mescher, Anthony Louis" <mescher at indiana.edu>
Date: Wed Sep 04, 2002  01:19:41 PM America/Winnipeg
To: "Axolotl Colony" <axolotl at indiana.edu>, 
<bionet-organisms-urodeles at net.bio.net>
Subject: RE: Lung regeneration

Sandi and Jill,
I looked in some older literature to check on amphibian lung
regeneration and found mention of some positive results in the axolotl
and in Bufo by a Russian (Solopayev) in the 1950's. I can't find the
exact reference and the work is just mentioned in the book on
regeneration by Vorontsova and Liosner. They make the point that
Weismann examined lung regeneration in the 1890's and reported that it
did not occur, but the newer studies indicate he was wrong. Regeneration
apparently occurs very, very slowly.
I really don't think there have been any more recent studies on lung
regrow at all in the US or Europe, in amphibians or any other animals.
Tony Mescher

-----Original Message-----
From: Axolotl Colony [mailto:axolotl at indiana.edu]
Sent: Thursday, August 29, 2002 12:34 PM
To: bionet-organisms-urodeles at net.bio.net
Subject: Lung regeneration

Hello all. We have a question about lung regeneration and we can't find
any references. Anyone out there have any ideas?

Axolotl Colony
Dr. Richard Gordon, Dept. of Radiology, U.Manitoba, Room GA216, 
Health Sciences Centre,
820 Sherbrook Street, Winnipeg, MB R3A 1R9 Canada
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