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Need EBV Genome DNA as a probe

Martin Kennedy mkennedy at chmeds.ac.nz
Thu Dec 2 21:05:36 EST 1993

In article <1993Dec1.222803.27211 at Virginia.EDU>, mgk2r at Virginia.EDU (Michael G. Kurilla) writes:
> frank at omrf.uokhsc.edu writes:
>> I am interested in looking at the site of integration of EBV in a cell line
>> I am working with.  Can someone send me some EBC genomic DNA to use as
>> a probe?  My understanding of EBV integration is that it is random. Is 
>> this correct?
>> Thanks in advance,
>> Bart Frank, Ph.D.

> If you asking about integration sites in the eukaryotic genome,
> then I would say that no one has really looked at enough sites
> to conclude if there is any pattern.
> Mike Kurilla

This reference might be of interest:

Lestou, V. et al. (1993)  Non-random integration of Epstein-Barr Virus in
lymphoblastoid cell lines.  Genes, chromosomes and cancer 8:38-48

They looked at integration sites in 15 lines, and claim integration was
non-random and there were preferential sites, particularly on chromosomes 1, 2,
4 and 5.



NNNN   NN  Martin A Kennedy (E-mail = mkennedy at chmeds.ac.nz)  ZZZZZZZ  
NN NN  NN       Cytogenetic and Molecular Oncology Unit          ZZZ
NN  NN NN           Christchurch School of Medicine            ZZZ
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