In article <1993Dec1.222803.27211 at Virginia.EDU>, mgk2r at Virginia.EDU (Michael G. Kurilla) writes:
>frank at omrf.uokhsc.edu writes:
>> I am interested in looking at the site of integration of EBV in a cell line
>> I am working with. Can someone send me some EBC genomic DNA to use as
>> a probe? My understanding of EBV integration is that it is random. Is
>> this correct?
>>>> Thanks in advance,
>> Bart Frank, Ph.D.
> If you asking about integration sites in the eukaryotic genome,
> then I would say that no one has really looked at enough sites
> to conclude if there is any pattern.
>> Mike Kurilla
This reference might be of interest:
Lestou, V. et al. (1993) Non-random integration of Epstein-Barr Virus in
lymphoblastoid cell lines. Genes, chromosomes and cancer 8:38-48
They looked at integration sites in 15 lines, and claim integration was
non-random and there were preferential sites, particularly on chromosomes 1, 2,
4 and 5.
--
Cheers,
Martin
NNNN NN Martin A Kennedy (E-mail = mkennedy at chmeds.ac.nz) ZZZZZZZ
NN NN NN Cytogenetic and Molecular Oncology Unit ZZZ
NN NN NN Christchurch School of Medicine ZZZ
NN NNNN Christchurch, New Zealand ZZZZZZZ
Phone (64-3)364-0880 Fax (64-3)364-0750
