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Need virological help with work of fiction

RYBICKI, ED ED at molbiol.uct.ac.za
Thu Oct 6 02:41:35 EST 1994

> From:          lehn at facstaff.wisc.edu
> In article <MAILQUEUE-101.941005094123.448 at molbiol.uct.ac.za>, 
> <ED at molbiol.uct.ac.za> writes:
> > > major plot device is an unusual form of airborne virus.  I 
> > 
> > The only kind of unusual form of airborne virus would be one 
that is 
> > totally unrealistic, ....
> Not so fast here.  Suppose for the sake of argument, that one
> were to insert the HIV genome into another virus......
> Lets see now, if HIV were cloned into vacinnia and the virus were
> grown up in large quantities and spayed in a fine aerosol over
> a large metropolitin area.  Eeeeeh! ...

Yeah, well, I was talking about NATURAL viruses here...and watch 
out, if the Rev. James reads this, he will report you to his cousin 
the law enforcement officer...!  But that really WOULD be a nasty, 
wouldn't it?  Under the control of a vaccinia late promoter, 
engineered so it initiated and terminated appropriately - and would 
presumably express appropriately from vaccinia.  BUT what about 
splicing?  Wouldn't get appropriate splices, wuld you, not being in 
the nucleus and all?  Would presumably make gag and maybe pol OK, 
but not env...unless the pol could work on non-encapsidated RNA, and 
you got appropriate genomic insertion, THEN the normal retrovirus 
expression.  Sounds like a "shoot when receive grant proposal" type 
of project to me!

 | Ed Rybicki, PhD          |         Well, I tip my hat           |
 | (ed at micro.uct.ac.za)     |      To the new constitution         |
 | Dept Microbiology        | Take a bow for the new revolution... |
 | University of Cape Town  |  Then I get on my knees and pray     |
 | Private Bag, Rondebosch  |   We don't get get fooled again...   |
 | 7700, South Africa       |                                      |
 | fax: xx27-21-650 4023    |      - Pete Townshend, 1972          |
 | tel: xx27-21-650 3265    |      (Won't get fooled again)        |

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