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fever and chickenpox

Chris Upton cupton at sol.uvic.ca
Fri Sep 16 12:25:19 EST 1994

Thanks for the info, here's a couple of responses (sorry if I lost the

I also found a bit of a review on the polio Abs and fever:
Trends in microbiol. vol2(7) p255  July 1994

But nothing on the effect of fever and recovery of chickenpox....
I KNOW I saw it somewhere!  :-)


In Article <Bernstein.30.0017ED77 at WSU-ID.Dayton.OH.US>,
Bernstein at WSU-ID.Dayton.OH.US (Jack M. Bernstein, M.D.) wrote:

>The comment re: aspirin is correct. Otherwise, there is really no adverse 
>event from fever reducing medications. The usual caveat is to use the meds 
>only when the patient is uncomfortable. Thus, tylenol for a fever of 38C may 
>not be needed or appropriate.

Perhaps you are thinking about Reye's syndrome. This is a poorly understood 
condition characterised by fatty infiltration of the liver and cerebral 
oedema. Epidemiologically it has been linked to the use of aspirin in 
chicken pox, but the exact nature of this link remains (to the best of my 
knowledge anyway) mysterious.

You might look at Delaet, I. and Boeye, A., J. Virol 67(9):5299-5312 (1993).
They showed that some monoclonal Ab neutralizes polio only at elevated temp. 
A citation search might find more recent refs.

Good luck,

Dr. Edwin C. Hahn
College of Veterinary Medicine
2001 S Lincoln Ave.
Urbana, IL 61801
Voice 217-333-8234
Pers. Fax -333-9034
Dept. Fax -244-7421
email e-hahn at uiuc.edu


Chris Upton 
Biochemistry & Microbiology
University of Victoria
PO Box 3055, Victoria
BC, Canada   V8W 3P6

(604)721-8855 fax

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