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pemphigus vulgaris

Giovanni Maga maga at vetbio.unizh.ch
Wed Nov 6 12:42:40 EST 1996

I just found these informations that maybe could be useful to you. I 
suggest you to discuss about them with your physician anyway.
Like other auto-immune disorders, in PV autoantibodies target a 
component of keratinocytes called "PVA". 
Researchers at the National Cancer Institute have successfully 
identified the DNA sequence of PVA and shown that it belongs to a family 
of cells called cadherins. These cadherins are commonly
involved in maintaining the structure of organs, including the body's 
largest organ -- the skin. The discovery that PVA is in fact a cadherin, 
offers new insight into how PV works to destroy and
disrupt normal bodily functions. 
Treatments, many quite successful, center on the
use of steroids such as prednisone and other corticosteroid medications. 
Chemotherapeutic immuno-suppressive drugs such as Imuran and Cytoxan are 
also administered to offset the disabling and toxic side effects of 
long-term prednisone use.
Ask your doctor about that.
I think your doctor is using antibiotics mainly to prevent infections of 
the lesions. However, it would be advisable to contact also a 
dermatologist for specific treatments like the ones mentioned above.
But remember: always take in consideration the doctor's suggestions! If, 
anyway your doctor does not satisfy you, go and visit a spacialist.
Do not start any drug treatment by yourself! That could be even more 
dangerous than the desease.
I think you can get informations, specialists' addresses and patient 
support at the e-mail: PVNEWS at AOL.com, or snail-mail: the National 
Pemphigus Vulgaris Foundation : 1098 Euclid Ave, Berkeley, CA 94708 :
Telephone 510.527.4970. 
Hope it helps. G. Maga.

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