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Mouse virus, NOT bone-marrow derived cells?

Ian A. York iayork at panix.com
Thu Nov 7 15:57:33 EST 1996

I get all the virus-related questions in our lab, and half the time I have
no idea what the answer is.  Here's what I was just asked:  My colleague
needs a virus which will infect mice, but which will not infect
bone-marrow-derived cells at all.  Although a bunch of things that are
very poor at infecting bm-derived cells sprang to mind, the block has to
be pretty much complete.  Moreover, the block needs to be at the level of
entry, because he's looking at cytotoxic T cells, which might see
structural proteins even if the virion can't replicate.

The papilloma viruses are one thought, but I don't know if there's a
complete block (or for that matter whether there's a block at all, come to
think of it).  I'm sure I should be able to come up with something else, 
but I'm drawing a blank.

It doesn't actually have to be a mouse virus, so long as it will infect
other mouse tissues.  It would be nice, too, if it's something that's
relatively easily acquired and relatively easy to work with.

Any suggestions?



      Ian York   (iayork at panix.com)  <http://www.panix.com/~iayork/>
      "-but as he was a York, I am rather inclined to suppose him a
       very respectable Man." -Jane Austen, The History of England

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