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Parvo virus and Fetal development

Paul Becquart becquart at infobiogen.fr
Thu Nov 14 17:40:59 EST 1996

: I am looking for information on the effects of Rat Parvo virus on
: offspring development.  Is anyone aware of fetal developmemt problems
: associated with breeding rats testing positive for parvo?  Is there
: inherant teratology associated with parvo?  Any input would be
: appreciated (first hand, colleague's, etc.)

in vitro Parvoviruses infect non-differenciated and dividing cells, as 
transformed cells, embryonic cells... In vivo, parvoviruses interfere with fetal
development, fetal death is observed when infection occured early in the 
development. The spectrum of syndromes reflects the state of histogenesis and 
organogenesis of the fetus at the time of infection. infected newborn animals 
develop either dwarfism and/or mongoloidlike features (osteolytic syndroms), 
adults are not affected by parvovirus infection.
you can find additionnal informations in "The parvoviruses" edited by Kenneth I.
Berns, Plenum publishing corporation, 233 Spring Street, New York, N.Y. 10013: 
The Viruses, Series editors: Heinz Fraenkel-Conrat and Robert R. Wagner.

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