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Parvo virus and Fetal development

Beno=EEt H=E9bert benoit_hebert at iaf.uquebec.ca
Mon Nov 18 18:48:50 EST 1996

Paul Becquart wrote:
> : I am looking for information on the effects of Rat Parvo virus on
> : offspring development.  Is anyone aware of fetal developmemt problems
> : associated with breeding rats testing positive for parvo?  Is there
> : inherant teratology associated with parvo?  Any input would be
> : appreciated (first hand, colleague's, etc.)
> in vitro Parvoviruses infect non-differenciated and dividing cells, as
> transformed cells, embryonic cells... In vivo, parvoviruses interfere w=
> development, fetal death is observed when infection occured early in th=
> development. The spectrum of syndromes reflects the state of histogenes=
is and
> organogenesis of the fetus at the time of infection. infected newborn a=
> develop either dwarfism and/or mongoloidlike features (osteolytic syndr=
> adults are not affected by parvovirus infection.
> you can find additionnal informations in "The parvoviruses" edited by K=
> Berns, Plenum publishing corporation, 233 Spring Street, New York, N.Y.=
> The Viruses, Series editors: Heinz Fraenkel-Conrat and Robert R. Wagner.
> PB

More recent:

Parvovirus Handbook (2 vol. ) CRC Press edited by Peter Tijssen
Seminars in Virology, last issue of 1995 devoted to parvoviruses

Benoit Hebert
Virology Research Center
Institut Armand-Frappier

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