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Ebola passive immunization

Freistadt, Marion mfreis at lsumc.edu
Thu Oct 3 12:42:55 EST 1996

>To:Brian Foley <btf at t10.lanl.gov>
>From:mfreis at lsumc.edu (marion freistadt)
>Subject:Re: Ebola passive immunization
>Re: Ebola passive immunization.
>There was an article in my local newspaper that passive immunization of Ebola
>infected patients worked in a few cases.  It may be real; however, these were
>not controlled studies and it is not clear if the patients would have
>recovered anyway.
>The reason this cannot be done for HIV infection (aside from all the
>practical, financial, and political problems) is because unlike Ebola, the
>natural immune response to HIV is not protective. (I know there are a few
>exceptions, but this, IMHO, is the central problem.)
>>Ian Nies wrote:
>>> Has anyone heard about the doctor in Zaire who injected
>>> a nurse that became
>>> infected with ebola virus, with the blood of a patient
>>> who survived ebola
>>> infection? The story is that the nurse having been
>>> injected with patient's
>>> blood recovered and survived ebola infection as a result .
>>> Sent on behalf of P. Nino, curious patient with AIDS.
>>        I have not heard that story.  However, it is possible.
>>Many diseases can be fought with such methods.  The patient
>>who survived the Ebola infection would have a high level of
>>antibodies against Ebola.  Thus a pint of blood from this
>>patient may have enough antibodies to fight the infection in
>>the nurse.  In order to give a pint of whole blood, the donor
>>and nurse would have to be of compatible blood types.  I
>>believe there is a method of purifying antibodies, so that
>>just the antibody fraction of blood is used, instead of whole
>>blood.  If I remember correctly, there have even been antibodies
>>raised in horses, which are used to fight Diphtheria in humans.
>>        However, not all diseases can be fought with such
>>methods.  Ebola virus causes a rapid/acute disease and HIV
>>does not.  There was a study:
>>F.Bex, P.Hermans, S.Sprecher, A.Achour, R.Badjou, C.Desgranges,
>>  J.Cogniaux, P.Franchioli, C.Vanhulle, and A.Lachgar.
>>Syngeneic adoptive transfer of anti-human immunodeficiency virus
>>  (HIV-1)-primed lymphocytes from a vaccinated HIV-seronegative
>>  individual to his HIV-1-infected identical twin.
>>Blood 8484:3317--3326, 1994.
>>        In which one of a pair of identical twins was vaccinated
>>against HIV, with the hope of saving the other twin from
>>HIV infection.  I think the long-term result was not successful,
>>but I am not sure.
>> ____________________________________________________________________
>>|Brian T. Foley                btf at t10.lanl.gov                      |
>>|HIV Database                  (505) 665-1970                        |
>>|Los Alamos National Lab       http://hiv-web.lanl.gov/index.html    |
>>|Los Alamos, NM 87544  U.S.A.  http://hiv-web.lanl.gov/~btf/home.html|

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