Two postdoctoral positions are available immediately in my laboratory
at Medical College of Georgia, Augusta, GA 30912. The focus of my lab
is on two related but separated subjects: tumor suppressor protein
p53-dependent apoptosis and cell cycle regulation. By using
tetracycline inducible promoter, we generated a number of cell lines
that express inducible p53 and p21. Recently, we cloned a number of
genes that potentially mediate p53-dependent apoptosis and cell cycle
arrest. My lab is well equipped and now has one energetic postdoc and
one well-trained research assistant. The following is some of my
recent publications:
Chen, X., L. Ko, and C. Prives. p53 levels, functional domains and DNA
damage determine the extent of the apoptotic response of tumor cells.
Genes & Dev. In Press.
Chen, X., G. Farmer, H. Zhu, R. Prywes, and C. Prives. 1993.
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism
for transcriptional activation. Genes & Dev. 7:1837-1849.
Chen, X., J. Bargonnetti, and C. Prives. 1995. p53, through p21
(WAF1/CIP1), induces cyclin D1 synthesis. Cancer Research.
55:4257-4263.
If you are interested, please e-mail your resume to
"xchen at mail.mcg.edu " or send your C.V. to Xinbin Chen, CB2803, IMMAG,
Medical College of Georgia, Augusta, GA 30912.
